Endocrine Abstracts

149 haemodialysis chronic renal failure (CRF) patients on haemodialysis (HD) program of 4 h/three times a week investigated for thyroid gland function and try to answer the question: is the thyroid function abnormality affect the response of the haemodialysis CRF patients response to recombinant human erythropoietin (rHuEPO)? We compare the results of the thyroid gland markers; T3, T4, and TSH (which tested by minividus technique) of the patients with the...

The effect of maternal diabetes on fetal pancreatic islets was investigated before, however an extensive and detailed quantitative immunocytochemical investigation was not found. Therefore, this investigation was conducted to examine the effect of gestational diabetes on the morphology of fetal rat islets. Sections were stained with anti-insulin (B cells) antibodies and were used for structural study. The absolute number of stained B cells per islet of the diabetic group was n...

Background: The presence of Adrenocorticotropic hormone (ACTH)-independent Cushing syndrome that is associated with androgen hypersecretion is extremely rare in benign adrenal tumors. Precise recognition and management of this association will have a great impact on the management of such patient.Clinical case: We describe a case of a 35-year-old lady who presented with 2 years history of difficult-to-control hypertension, symptoms of androgen excess alo...

Bisphenol A (BPA) is a byproduct of polycarbonate plastic widely present in food containers. BPA is historically a known endocrine disruptor and due to its oestrogen agonist activity, BPA consumption is associated with hypothyroidism and reproductive disorder. Recent studies have shown that oestrogen antagonised GH actions. Since BPA has oestrogen agonist activity, the effect of BPA exposure on GH activity has not yet been investigated.Aim: To study the ...

Ovarian cancer is one of the major cause of death among women worldwide with high incidence. Ovarian cancer can be categorized into epithelial, non-epithelial (germ cell and sex cord-stromal cell), and metastatic (usually develop from surrounding cancerous organs). Recently, several approaches have been studied to control ovarian cancer at the transcriptional or post-transcriptional levels using small non coding RNAs including microRNAs. We carried out a meta-analysis of previ...

Introduction: Clinicians are hopeful for substantial weight loss after surgical intervention for obesity, with the funding decisions relatively easier to achieve in those with diabetes, there is a significant proportion of these patients undergoing procedures. In contrast to most outpatient encounters, a 20 kg drop in weight is looked upon favourably between follow-ups where it would have risen the spectre of pathology elsewhere. We present the following case that illustrates ...

Introduction: Hypophysitis is a rare association of inflammatory bowel disease (IBD) with only few cases reported in the literature. It can present with isolated hormone deficiencies or panhypopituitarism. Patients may also present with symptoms secondary to inflammatory pituitary mass. Management consists of hormone replacement therapy, but high dose steroids, steroid sparing agents like Rituximab or even surgery may be required for mass effect.Case rep...

40years old lady with 12 months history of hyperthyroidism. Treated with ATD. Referred by her treating physician for RAI therapy due to intolerance to ATD and high dose requirement after 12 months. Patient being treated as Classical Graves’ Hyperthyroidism. She had symptoms of hyperthyroidism at time of presentation but none at time of assessment in our hospital. Main current issue was painful neck swelling: developed slowly over preceding two months. No problems with swa...

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome and is more often diagnosed as bilateral adrenal incidentalomas with subclinical cortisol production. It is mainly a heterogeneous disease, but familial cases have been reported. Treatment of PBMAH with overt Cushing’s syndrome is usually bilateral adrenalectomy with unilateral adrenalectomy occasionally used to normalize urinary free cortisol (UFC) in patie...

Introduction: Familial dysalbuminemic hyperthyroxinemia (FDH) is a familial autosomal dominant condition that was first reported in 1979. It is caused by a mutant albumin molecule with an increased affinity for serum thyroxine (T4), despite the serum albumin level being normal. FDH causes increase in total T4 and T3 level with normal TSH level. As FDH patients are clinically euthyroid and asymptomatic, they do not require treatment.Case report: 68-year-o...